Fiorello H. LaGuardia (1882–1947) was born in New York City to immigrant parents, attended public schools and graduated from New York University Law School in 1910. After practicing law for several years, he was elected as the nation’s first Italian American member of Congress in 1916. He served as a U.S. Representative until 1919, when he resigned to join the Army Air Service and serve in World War I. Upon his return, he was president of the New York City Board of Aldermen in 1920 and 1921, and was re-elected to Congress from 1923 to 1933. LaGuardia then served as mayor of New York City from 1934 to 1945.

Among LaGuardia's many achievements as mayor, he is credited with unifying and modernizing New York City's public transit system, consolidating much of the city government, cracking down on illegal gambling, and beginning transportation projects that created many of the city’s bridges, tunnels, parkways and airports. He was also instrumental in the establishment of Queens College.

In September 1937, Mayor LaGuardia broke ground on this airport's site. Its construction was funded through a $45 million Federal Works Progress Administration grant. More than half of the 558 acres on which the airport was built was man-made, filled in with more than 17 million cubic yards of cinders, ashes and trash.

The new airport opened in 1939 as New York City Municipal Airport. In August 1940, the Board of Estimates renamed the facility for LaGuardia, who considered the project one of his greatest achievements. Today it is the third largest airport in the New York metropolitan area.